Image Gallery: Mutilating diffuse cutaneous leishmaniasis in AIDS

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Diabetes mellitus associated with pentamidine isethionate in diffuse cutaneous leishmaniasis.

The authors report a case of a male patient from Bacabal, MA with diffuse cutaneous leishmaniasis (DCL), for at least nine years, with 168 lesions on his body. These were tumour-like nodules with some ulceration. He used pentavalent antimonial (glucantime) and an association of gamma interferon plus glucantime with improvement of the lesions but relapsed later. Recently, pentamidine isethionate...

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Diffuse cutaneous leishmaniasis responds to miltefosine but then relapses.

BACKGROUND Diffuse cutaneous leishmaniasis (DCL), although rare, is profoundly incapacitating. At present there is no successful treatment for this progressive protozoan infection, which is associated with the absence of specific cell-mediated immunity (CMI) to Leishmania. This disease shares features with visceral leishmaniasis (VL), including specific CMI inactivity during active disease and ...

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[Diffuse cutaneous leishmaniasis (DCL) and visceral leishmaniasis (VL) concurrent with cancer: Presentation of a case].

Male of 52 year old with chronic alcoholism and ulcerated lesion on the face and disseminated nodular skin lesions, underwent to biopsy of ulcer edges where was observed a concomitant epidermoid malignancy with Leishmania (L.). Besides others, biopsies of nodule in the periumbilical region, lymph node and bone marrow were assayed, and all biopsies had abundant amastigotes. The amplified Polymer...

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[Cutaneous leishmaniasis].

Cutaneous leishmaniasis is endemic in certain tropical and sub-tropical regions, and is sometimes encountered as an imported disease in Norway. The disease is characterized by chronic and painless, but often disfiguring, ulcers that regress after some months to years, leaving atrophic scars. Diagnosis is established by demonstrating amastigote Leishmania bodies by microscopy of Giemsa-stained s...

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Cutaneous Leishmaniasis

Transforming growthfactor (TGF)-,8 has several downregulatoryfunctions on the immune systenm inhibition ofinterleukin-2 receptor induction, decrease of interferon-yinduced class II antigen expression, inhibition of macrophage activation, as weUl as cytotoxic and lymphokineactivated kilter cell generation. TGF-(8 has also been recognized as an important immunoregulator in murine leishmaniasis, f...

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ژورنال

عنوان ژورنال: British Journal of Dermatology

سال: 2019

ISSN: 0007-0963,1365-2133

DOI: 10.1111/bjd.18367